Preheat oven to 325 degrees F. Generously and thoroughly grease and flour a 10-inch (12-cup) Bundt pan (I also sugar the pan.) Please see Notes.
In a medium bowl, whisk together flour, baking powder, baking soda and salt. Set aside.
Whisk buttermilk with 2 tablespoons lemon juice, 2 tablespoons lemon zest and 1 tablespoon vanilla in a liquid measuring cup; set aside.
Add butter and sugar to a stand mixer fitted with the paddle attachment and beat on medium-high speed for at least 3-4 minutes (no less!), until light and fluffy, scraping down sides occasionally. Reduce speed to medium and add eggs, one at a time, beating just until the yellow disappears after each egg.
Reduce speed to low and gradually add flour mixture to butter mixture in thirds, alternately with buttermilk mixture in between each third. Beat just until combined, giving the batter a final stir by hand to get any flour at the bottom.
Transfer batter to the prepared Bundt pan and tap the pan on the counter a few times to get rid of any air bubbles. Bake at 325 degrees F until a wooden pick inserted near the center of cake comes out with a few crumbs, 55- 70 minutes.
Place cake on a wire rack and let rest 5 minutes then poke holes all over the cake, going about ¾ of the way down using the thin end of a chopstick. You may also use the back of a utensil or a skewer, but you’ll want wiggle it around so the holes become larger.